In-file delta technology is an advanced data block matching algorithm which has the intelligence to pick up changes (delta) of file content between two files. Using this algorithm, daily backing up of large files (e.g. a 10GB Outlook.pst file) over low-speed internet connection is made possible because it requires only the changes of information (should be marginal) since the last backup to be sent over a low-speed internet connection to complete the backup of a large file (here we assume that the full backup of the file has been saved on the backup server already).
You can read more about it in the In-File Delta Whitepaper found here